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In bladder cancer cells, erianin evoked ferroptosis by inducing NRF2 inactivation characterized by decreased FTH1, GPX4, HO-1, and xCT/SLC7A11 expression as well as the accumulation of ROS and the depletion of GSH (Xiang et al., 2021)

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As early as 2009, Shankar had proposed that mitochondria released from necrotic cells activated NLRP3 inflammasome, but the process was inhibited by respiratory chain inhibitors such as rotenone